Board of Directors

Joining David Katona on the Nanocare Board of Directors are Barry R. Frankel, MBA, Managing Director of the Huron Consulting Group; Steve Klein JD, Co-Founder, Partner and CEO of Apple Core Holdings; and Constance McKee, MBA, President & CEO of Manzanita Pharmaceuticals, Inc. The Board is actively recruiting additional Board members with scientific and clinical expertise in cancer drug development.



Barry R. Frankel, MBA


Barry Frankel founded Frankel Group in March of 1993. Following nearly 20 years in the life science industry, spanning investment research, strategic planning/M&A and marketing, Barry saw an opportunity to pull together a unique team of experienced professionals from suppliers, providers, banking and consulting to capitalize on the emerging new business models required and provide financially grounded, strategic solutions to the life science industry. Frankel Group is now part of Huron Consulting Group.


Since forming Frankel Group/Huron Consulting, Barry has focused on business model transformation and its key technology and commercial components. Clients have spanned multinational and specialty pharmaceutical companies, emerging bio/pharmaceutical firms, device and diagnostic companies, industry intermediaries including CRO's and CSO's, and a range of investment firms.


Barry also has served on the Board of Directors of Inspiration Biopharmaceuticals (sold to Baxter and Cangene), Molecular Insight Pharmaceuticals (merged into Progenics), Synthemed (merged into Pathfinder), and Berkeley HeartLab (sold to Celera). Barry’s current board assignments include Cireca Theranostics and the Center for the Commercialization of Regenerative Medicine.



Steve Klein

Co-Founder, Partner, CEO of Apple Core Holdings


Steve Klein is the Co-Founder, Partner, and CEO of Apple Core Holdings, a diversified private investment company. He is also the CEO of Apple Core Hotels, which owns and operates five hotels in midtown Manhattan.


Steve sits on many of the boards of Apple Core Holdings' direct investments including Zeno Radio, Gotham Hall Events and Bengal Capital. He is a venture partner for Shavit Capital Fund in Israel. In addition to Nanocare Technologies, Apple Core Holdings' recent biotech investments include Brainsway and ReWalk (NASDAQ: RWLK). Before founding Apple Core Hotels, Steve began his career in New York as a corporate tax attorney at Skadden Arps, where he practiced from 1990 – 1992. He has also written, directed and produced for both film and theater including producing the film “Passing Strange” in 2009 together with Spike Lee, which Mr. Lee also directed. Steve wrote and directed the feature film “Game Day” starring Richard Lewis.


Steve holds a JD magna cum laude from Boston University Law School and a Master’s Degree in tax law from New York University Law School. He received his Bachelor of Science in business from the State University of New York in Albany.



Constance McKee, MBA


Constance McKee is founder, President & CEO of Manzanita Pharmaceuticals, Inc (2007-present).  Manzanita is developing non-opiate pain drugs, including a novel pain medication to treat a rare form of children’s cancer, and a nerve imaging agent. She wrote and serves as co-Principal Investigator with Stephen B. Kahl, PhD, on the company’s SBIR Phase I grant from the National Cancer Institute to develop the company’s nerve imaging agent.


In 2010 she founded i2 Grants Associates, a consulting firm that identifies sources of non-equity diluting capital and prepares grants for NIH, military, and foundation funding for for-profit and nonprofit clients.  Since launching, Constance and her associates have helped her clients secure about $8M in funding.


From 1990-1994, Constance was Chief Executive of Cambridge Quantum Fund I, a £1M seed venture fund investing in technologies from Cambridge University (Cambridge, UK). Three of Cambridge Quantum Fund’s portfolio companies were leveraged with non-equity diluting corporate capital. After returning to Silicon Valley in 1995, from 1996-2001 she worked in the corporate venture capital group and in General Counsel’s office at Philips Semiconductors, where she was involved with 20+ venture, M&A, and licensing transactions.


Constance holds an MBA from Yale University School of Management, and a BA with distinction from Stanford University. In the past 12 years she has returned each year to Yale to guest teach “Business of Biotechnology” a week-long course at Yale.



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